This project, led by Johnathan Lancaster, MD, PhD, was one of the original Moffitt Cancer Center NFGC pilot projects and resulted in several publications. As a result in part of data obtained from this pilot project, Dr. Lancaster et al. published in the February 10, 2007 edition of the prestigious Journal of Clinical Oncology (Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsburg GS, Potti A, West M, Nevins JR, Lancaster JM. An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. J Clin Oncol. 2007 Feb 10;25(5):517-25. PMID: 17290060 ). The authors conclude, “We have defined a strategy for treatment of patients with advanced-stage ovarian cancer that uses therapeutic stratification based on predictions of response to chemotherapy, coupled with prediction of oncogenic pathway deregulation, as a method to direct the use of targeted agents.”
Additional publications that resulted from this project include: Berchuck A, Iversen ES, Lancaster JM, Pittman J, Luo J, Lee P, Murphy S, Dressman HK, Febbo PG, West M, Nevins JR, Marks JR. Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers. Clin Cancer Res. 2005 May 15;11(10):3686-96. PMID: 15897565.
Berchuck A, Iversen ES, Lancaster JM, Dressman HK, West M, Nevins JR, Marks JR. Prediction of optimal versus suboptimal cytoreduction of advanced-stage serous ovarian cancer with the use of microarrays. Am J Obstet Gynecol. 2004 Apr;190(4):910-25. PMID: 15118612.
Page updated 12/7/07